CALEY JAGS defender Ross Tokely is facing a further two weeks on the sidelines with a calf injury.
Richie Foran and Gil Blumenshtein are also missing but Kevin McCann is expected to return after missing the Co-operative Cup tie with Peterhead.
Hamilton will be without Jack Ross and Stuart Elliot after releasing the pair from their contracts.
Martin Canning is suspended, while Alex Neil, Mark McLaughlin and David Elebert are still injured.
Inverness defender Grant Munro told BBC Scotland: "Hamilton will be a wounded animal and they'll be desperate to bounce back from that defeat to Raith Rovers on Tuesday.
"I'm sure they'll be working hard on coming here to frustrate us and get their season off and running.
"We can't be complacent whatsoever, last week's gone now and we've taken the plaudits but it's all about getting down to work and making sure we get the right result on Saturday.
"We have struggled against them, there's been a few draws between us and they've beaten us on a few occasions.
"They're a very disciplined side and know what they're doing, but with their confidence low and ours high, maybe we can get an early goal and put them on the back foot."
Inverness (from): Esson, McCann, Munro, Proctor, Gillet, Cox, Duncan, Hayes, Ross, Odhiambo, Rooney, McBain, Tuffey, Golabek, Sanchez, Sutherland, Morrison, Shinnie.
Hamilton (from): Cerny, McDonald, Gillespie, Skelton, Lyle, Mensing, McQueen, McAlister, Thomas, Routledge, Imrie, Marco Paixao, Hasselbaink, Flavio Paixao, Murdoch, Buchanan, Kirkpatrick, Graham.
Source: BBC Sport
Source: BBC Sport