Celtic will be without captain Scott Brown, who has an ankle problem, and shoulder injury victim Paddy McCourt.James Forest is also out while defender Jos Hooiveld sustained a training injury on Tuesday and will be assessed before the third round tie.
Inverness are short of defenders with Chris Innes, Kevin McCann and Kenny Gillet all sidelined.
Strikers Dani Sanchez and Gil Blumstein also miss the trip to Celtic Park with knee and calf problems respectively.
Celtic (from): Forster, Loovens, Cha Du-Ri, Majstorovic, Izaguirre, Murphy, Ledley, Samaras, Maloney, Wilson, Rogne, Hooiveld, Hooper, Stokes, Kayal, Zaluska, Juarez, Ki, Towell, Mulgrew.
Inverness CT (from): Esson, Tokely, Proctor, Munro, Golabek, Cox, Duncan, McBain, Duff, Hayes, Ross, Odhiambo, Rooney, Sutherland, Foran, Tuffey.
Source: BBC Sport
Source: BBC Sport